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multiple endocrine neoplasia type 2B

An autosomal dominant disorder caused by specific pathogenic variants in the RET gene, characterized by an increased risk of very early onset medullary thyroid carcinoma, pheochromocytoma, and hyperparathyroidism, and mucosal neuromas.

Therapeutic area: Endocrine / Metabolic
Rarity: Unknown
Prevalence: —
MONDO: MONDO:0008082

Overview

An autosomal dominant disorder caused by specific pathogenic variants in the RET gene, characterized by an increased risk of very early onset medullary thyroid carcinoma, pheochromocytoma, and hyperparathyroidism, and mucosal neuromas.

Content last reviewed: 2026-06