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Regulatory intelligence — not medical or legal advice.

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Requires OPENAI_API_KEY on the server. Heuristics always run first.

Diseases
2,318
Top-row linked drugs
27
Top-row references
12
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Prevalence
DiseaseRarityPrevalenceDrugsRefs
systemic lupus erythematosus
MONDO:0005187
rare~500k patients (est.)11620
sickle cell disease
MONDO:0005079
rare~100k US / ~20M globally (est.)220
systemic lupus erythematosus
MONDO:0007915
rare~500k patients (est.)670
sickle cell disease due to hemoglobin S and a non-S/non-C hemoglobin variant
MONDO:0979354
rare~100k US / ~20M globally (est.)00
sickle cell disease
MONDO:0011382
rare~100k US / ~20M globally (est.)70
hemophilia A
MONDO:0010602
ultra rare~400k patients (est.)90
hemophilia A
MONDO:0009691
ultra rare~400k patients (est.)1060
nephrotic syndrome
MONDO:0005377
rare~100k patients (est.)3170
occipital horn syndrome
MONDO:0010572
rare~100k patients (est.)10
cytokine release syndrome
MONDO:0600008
rare~100k patients (est.)20
restless legs syndrome
MONDO:0005391
rare~100k patients (est.)1160
congenital adrenal hyperplasia
MONDO:0018479
rare~100k patients (est.)11860
idiopathic pulmonary fibrosis
MONDO:0007263
rare~100k patients (est.)600
Prader-Willi syndrome
MONDO:0008300
rare~100k patients (est.)60
irritable bowel syndrome
MONDO:0005052
rare~100k patients (est.)2710
Hutchinson-Gilford progeria syndrome
MONDO:0008310
rare~100k patients (est.)10
congenital heart disease
MONDO:0005453
rare~100k patients (est.)1260
congenital or acquired
MONDO:0021139
rare~100k patients (est.)4510
idiopathic pulmonary fibrosis
MONDO:0800504
rare~100k patients (est.)440
Lennox-Gastaut syndrome
MONDO:0016532
rare~100k patients (est.)5330
Wiskott-Aldrich syndrome
MONDO:0010518
rare~100k patients (est.)50
Zollinger-Ellison syndrome
MONDO:0019610
rare~100k patients (est.)11650
acute radiation syndrome
MONDO:0033938
rare~100k patients (est.)90
Duchenne muscular dystrophy
MONDO:0010679
rare~100k patients (est.)200
carcinoid syndrome
MONDO:0100347
rare~100k patients (est.)100
Sjogren syndrome, domestic cat
MONDO:7770552
rare~100k patients (est.)00
polyendocrine syndrome, dog
MONDO:7770380
rare~100k patients (est.)00
paroxysmal dystonia-ataxia syndrome, TNR-related, dog
MONDO:7770208
rare~100k patients (est.)00
Sharpin-related autoinflammatory syndrome
MONDO:1040029
rare~100k patients (est.)00
periodic fever syndrome, HAS2-related, dog
MONDO:1013791
rare~100k patients (est.)00
tumor lysis syndrome, non-human animal
MONDO:1013230
rare~100k patients (est.)00
perinatal mortality syndrome, GCK-related, cattle
MONDO:1012939
rare~100k patients (est.)00
Waardenburg syndrome, MITF-related, golden hamster
MONDO:1012677
rare~100k patients (est.)00
Waardenburg syndrome, domestic cat
MONDO:1011617
rare~100k patients (est.)00
Phelan-McDermid syndrome, crab-eating macaque
MONDO:1010425
rare~100k patients (est.)00
persistent Mullerian duct syndrome, non-human animal
MONDO:1010278
rare~100k patients (est.)00
stiff skin syndrome, non-human animal
MONDO:1010147
rare~100k patients (est.)00
TFAP2B-related congenital heart disease spectrum disorder
MONDO:1010098
rare~100k patients (est.)00
Meier-Gorlin syndrome 9
MONDO:0980992
rare~100k patients (est.)00
multiple mitochondrial dysfunctions syndrome 7
MONDO:0957382
rare~100k patients (est.)00
Radio-Tartaglia syndrome
MONDO:0859143
rare~100k patients (est.)00
neonatal/infantile-onset epilepsy syndrome with developmental and epileptic encephalopathy
MONDO:0800490
rare~100k patients (est.)00
Stüve-Wiedemann syndrome 1
MONDO:0800043
rare~100k patients (est.)00
newborn respiratory distress syndrome
MONDO:0700081
rare~100k patients (est.)00
SOX11-related complex neurodevelopmental disorder with or without congenital anomalies
MONDO:0100626
rare~100k patients (est.)00
Jeune syndrome - GRK2-related
MONDO:0100583
rare~100k patients (est.)00
RBFOX2-related congenital heart disorder
MONDO:0100557
rare~100k patients (est.)00
Sunflower syndrome
MONDO:0100529
rare~100k patients (est.)00
NKX2-1 related choreoathetosis and congenital hypothyroidism with or without pulmonary dysfunction
MONDO:0100520
rare~100k patients (est.)00
multiple congenital anomalies due to 14q32.2 paternally expressed gene defect
MONDO:0100507
rare~100k patients (est.)00
NTHL1-deficiency tumor predisposition syndrome
MONDO:0100502
rare~100k patients (est.)00
multiple congenital anomalies due to 14q32.2 imprinting defect
MONDO:0100499
rare~100k patients (est.)00
titinopathy with congenital contractures
MONDO:0100497
rare~100k patients (est.)00
MECOM-associated syndrome
MONDO:0100458
rare~100k patients (est.)00
port-wine nevi-mega cisterna magna-hydrocephalus syndrome
MONDO:0100367
rare~100k patients (est.)00
POLD1-related polyposis and colorectal cancer syndrome
MONDO:0100351
rare~100k patients (est.)00
LADD syndrome 1
MONDO:0100302
rare~100k patients (est.)00
Olmsted syndrome 1
MONDO:0100296
rare~100k patients (est.)00
POLE-related polyposis and colorectal cancer syndrome
MONDO:0100287
rare~100k patients (est.)00
overgrowth syndrome and/or cerebral malformations due to abnormalities in MTOR pathway genes
MONDO:0100283
rare~100k patients (est.)00
Roberts-SC phocomelia syndrome
MONDO:0100253
rare~100k patients (est.)00
restless legs syndrome, susceptibility to
MONDO:0100170
rare~100k patients (est.)00
retinal dystrophy-ataxia-pituitary hormone abnormality-hypogonadism syndrome
MONDO:0100155
rare~100k patients (est.)00
Dravet syndrome
MONDO:0100135
rare~100k patients (est.)30
Uner Tan Syndrome
MONDO:0100144
rare~100k patients (est.)00
pediatric acute respiratory distress syndrome
MONDO:0100131
rare~100k patients (est.)00
NAA10-related syndrome
MONDO:0100124
rare~100k patients (est.)00
Middle East respiratory syndrome
MONDO:0100116
rare~100k patients (est.)00
Zinner syndrome
MONDO:0100109
rare~100k patients (est.)00
LEOPARD syndrome 1
MONDO:0100082
rare~100k patients (est.)00
acute coronary syndrome
MONDO:0005542
rare~100k patients (est.)1620
SLC10A7-congenital disorder of glycosylation
MONDO:0100068
rare~100k patients (est.)00
Usher syndrome, type 1D/F
MONDO:0100050
rare~100k patients (est.)00
neonatal/infantile epilepsy syndrome
MONDO:0100022
rare~100k patients (est.)00
structural congenital heart disease, multiple types - GATA4
MONDO:0100009
rare~100k patients (est.)00
secondary mast cell activation syndrome
MONDO:0100006
rare~100k patients (est.)00
MED12-related intellectual disability syndrome
MONDO:0100000
rare~100k patients (est.)00
orofaciodigital syndrome 18
MONDO:0054770
rare~100k patients (est.)00
Stankiewicz-Isidor syndrome
MONDO:0054591
rare~100k patients (est.)00
large congenital melanocytic nevus
MONDO:0044792
rare~100k patients (est.)00
nephrotic syndrome of childhood - steroid sensitive
MONDO:0044781
rare~100k patients (est.)00
X-linked congenital stationary night blindness
MONDO:0044749
rare~100k patients (est.)00
muscular dystrophy
MONDO:0020121
rare~100k patients (est.)200
Rahman syndrome
MONDO:0044323
rare~100k patients (est.)00
Shwachman-Diamond syndrome 1
MONDO:0044204
rare~100k patients (est.)00
Jaffer-Beighton syndrome
MONDO:0023510
rare~100k patients (est.)00
Jacobsen syndrome, cattle
MONDO:1010516
rare~100k patients (est.)00
intrauterine growth restriction-congenital multiple café-au-lait macules-increased sister chromatid exchange syndrome
MONDO:0034991
rare~100k patients (est.)00
Jervell and Lange-Nielsen syndrome 1
MONDO:0024540
rare~100k patients (est.)00
Jeune syndrome
MONDO:0018770
rare~100k patients (est.)00
isolated congenital auditory ossicle malformation
MONDO:0015570
rare~100k patients (est.)00
isolated congenital megalocornea
MONDO:0010649
rare~100k patients (est.)00
Jawad syndrome
MONDO:0009622
rare~100k patients (est.)00
jaw-winking syndrome
MONDO:0007946
rare~100k patients (est.)012
Jacobsen syndrome
MONDO:0007838
rare~100k patients (est.)00
isolated congenital anosmia
MONDO:0007137
rare~100k patients (est.)00
Kariminejad neurodevelopmental syndrome
MONDO:0975795
rare~100k patients (est.)00
Karayol-Borroto-Haghshenas neurodevelopmental syndrome
MONDO:0975836
rare~100k patients (est.)00
Kaplowitz-Bodurtha syndrome
MONDO:0023538
rare~100k patients (est.)00
juvenile-onset diabetes mellitus-central and peripheral neurodegeneration syndrome
MONDO:0014523
rare~100k patients (est.)00